Circadian Rhythm Disruption and Metabolic Dysfunction

Structured Summary

Circadian biology coordinates endocrine timing, glucose handling, and sleep architecture. When light exposure and behavioral timing are inconsistent, central and peripheral clocks become misaligned.

Multiple studies indicate that chronic phase delay and schedule variability are associated with reduced insulin sensitivity and impaired metabolic flexibility.

Mechanism Pathway

Circadian disruption

↓

Melatonin/cortisol timing mismatch

↓

Glucose handling variability and elevated stress signaling

↓

Higher metabolic strain baseline

Alignment Relevance

• Pillar: Lifestyle
• Domains: Sleep Rhythm, Circadian Behavior

This evidence supports the framework's emphasis on rhythm stability over isolated interventions.

Plain Language Takeaway

Consistent sleep-wake timing and light exposure patterns can reduce cumulative metabolic divergence.